Technische Universität München
Professur für Physik der Biomedizinischen Bildgebung (Prof. Herzen)
James-Franck-Str. 1
85748 Garching b. München
Academic Program Director: Study Programs in Physics, Biomedical Engineering and Medical Physics, and Quantum Science and Technology
We develop novel X-ray imaging methods using highly brilliant synchrotron radiation and conventional laboratory X-ray sources. We mainly focus on quantitative multi-modal approaches combining spectral and phase-contrast imaging. Currently, we are aiming at applying these methods for improved breast cancer detection and for quantitative 3D virtual histology of human tissue.
Advanced Science
Abstract: Virtual histology using X-ray micro-computed tomography offers 3D tissue visualization, yet lacks the specificity of conventional histology, where targeted stains selectively highlight features like…
Light: Science and Applications
Abstract: Dark-field X-ray imaging visualizes structural inhomogeneities through small-angle scattering, but existing directional methods are confined to the micrometer scale. While recent advances have…
IEEE Transactions on Image Processing
Abstract: Recent advances in propagation-based phase-contrast imaging, such as hierarchical imaging, have enabled the visualization of internal structures in large biological specimens and material samples.…
Optica
Abstract: X-ray microtomography at synchrotron sources is fundamentally limited by the high radiation dose applied to the samples, which restricts investigations to non-native tissue states and thereby…
Pharmaceutics
Abstract: Background/Objectives: Cardiovascular and pulmonary diseases are leading comorbidities n individuals with Down syndrome (DS). Although clinically well described, preclinical models fully…
Scientific Reports
Abstract: Phase-contrast micro-tomography (CT) with synchrotron radiation can aid in the differentiation of subtle density variations in weakly absorbing soft tissue specimens. Modulation-based imaging (MBI)…
Medical Physics
Abstract: Background: A significant proportion of false positive recalls of mammography-screened women is due to benign breast cysts and simple fibroadenomas. These lesions appear mammographically as…
Frontiers in Immunology
Abstract: This study identifies and characterizes previously unrecognized medullary B cell niches within murine mucosa-draining lymph nodes (LNs), challenging the conventional understanding of LN architecture.…
Scientific Reports
Abstract: Accurately monitoring the extent of freezing in biological tissue is an important requirement for cryoablation, a minimally invasive cancer treatment that induces cell death by freezing tissue with a…
IEEE Transactions on Medical Imaging
Abstract: X-ray dark-field imaging enables a spatially-resolved visualization of ultra-small-angle X-ray scattering. Using phantom measurements, we demonstrate that a material’s effective dark-field signal may…
