Dr. rer. nat. Martin Kulke

Technische Universität München

Lehrstuhl für Theoretische Biophysik - Molekulardynamik (Prof. Zacharias)

Postadresse

Postal:
Ernst-Otto-Fischer-Str. 8
85748 Garching b. München

Tel.: +49 (89) 289 - 13766
Fax: fax +49 (89) 289 - 12444
Raum: 5415.EG.048
Homepage: https://www.groups.ph.tum.de/t38/home/
martin.kulke@tum.de

Research Interests

Protein-protein and protein-membrane interfaces
Dynamic properties of protein, lipids and small organic compounds in liquid environments
Enhanced sampling techniques
Multiscale modeling

Publications

Year	Authors, Title, Journal
2024	Parson, W.W..; Huang, J.; Kulke, M.; Vermaas J.V.; Kramer D.M. Electron transfer in a crystalline cytochrome with four hemes The Journal of Chemical Physics 2024, 160 (6), 065101
2024	Kulke, M.; Kurtz, E.; Boren, D.M.; Olson, D.M.; Koenig, A.M., Hoffmann-Benning, S.; Vermaas, J.V. PLAT domain protein 1 (PLAT1/PLAFP) binds to the Arabidopsis thaliana plasma membrane and inserts a lipid Plant Science 2024, 338, 111900
2023	Weraduwage S.M.; Whitten, D.; Kulke, M.; Sahu, A.; Vermaas, J.V.; Sharkey, T.D. The isoprene-responsive phosphoproteome provides new insights into putative signalling pathways and novel roles of isopren Plant, Cell, & Environment 2023, pce.14776
2023	Kulke., M.; Olson, D.M.; Huang, J.; Kramer, D.M.; Vermaas, J.V. Long-Range Electron Transport Rates Depend on Wire Dimensions in Cytochrome Nanowires Small 2023, 19, 2304013
2023	Kulke, M.; Weraduwage, S. M.; Sharkey, T. D.; Vermaas, J. V. Nanoscale Simulation of the Thylakoid Membrane Response to Extreme Temperatures. Plant Cell & Environment 2023, pce.14609
2023	Weraduwage, S. M.; Sahu, A.; Kulke, M.; Vermaas, J. V.; Sharkey, T. D. Characterization of Promoter Elements of Isoprene‐responsive Genes and the Ability of Isoprene to Bind START Domain Transcription Factors Plant Direct 2023, 7 (2)
2023	Sarkar, D.; Kulke, M.; Vermaas, J. V. LongBondEliminator: A Molecular Simulation Tool to Remove Ring Penetrations in Biomolecular Simulation Systems Biomolecules 2023, 13 (1), 107
2022	Kulke, M.; Vermaas, J. V. Reversible Unwrapping Algorithm for Constant-Pressure Molecular Dynamics Simulations J. Chem. Theory Comput. 2022, 18 (10), 6161–6171
2022	Schulig, L.; Geist, N.; Delcea, M.; Link, A.; Kulke, M. Fundamental Redesign of the TIGER2hs Kernel to Address Severe Parameter Sensitivity J. Chem. Inf. Model. 2022, 62 (17), 4200–4209
2022	Ayala Mariscal, S. M.; Pigazzini, M. L.; Richter, Y.; Özel, M.; Grothaus, I. L.; Protze, J.; Ziege, K.; Kulke, M.; ElBediwi, M.; Vermaas, J. V.; Colombi Ciacchi, L.; Köppen, S.; Liu, F.; Kirstein, J. Identification of a HTT-Specific Binding Motif in DNAJB1 Essential for Suppression and Disaggregation of HTT Nat Commun 2022, 13 (1), 4692
2021	Zwicker, P.; Geist, N.; Göbler, E.; Kulke, M.; Schmidt, T.; Hornschuh, M.; Lembke, U.; Prinz, C.; Delcea, M.; Kramer, A.; Müller, G. Improved Adsorption of the Antimicrobial Agent Poly (Hexamethylene) Biguanide on Ti-Al-V Alloys by NaOH Treatment and Impact of Mass Coverage and Contamination on Cytocompatibility Coatings 2021, 11 (9), 1118
2021	Kulke, M.; Nagel, F.; Schulig, L.; Geist, N.; Gabor, M.; Mayerle, J.; Lerch, M. M.; Link, A.; Delcea, M. A A Hypothesized Mechanism for Chronic Pancreatitis Caused by the N34S Mutation of Serine Protease Inhibitor Kazal-Type 1 Based on Conformational Studies J. Inflamm. Res. 2021, Volume 14, 2111–2119
2021	Schulig, L.; Grabarczyk, P.; Geist, N.; Delin, M.; Forkel, H.; Kulke, M.; Delcea, M.; Schmidt, C. A.; Link, A. Unveiling the N-Terminal Homodimerization of BCL11B by Hybrid Solvent Replica-Exchange Simulations Int. J. Mol. Sci. 2021, 22 (7), 3650
2021	Buchholz, I.; McDonnell, T.; Nestler, P.; Tharad, S.; Kulke, M.; Radziszewska, A.; Ripoll, V. M.; Schmidt, F.; Hammer, E.; Toca-Herrera, J. L.; Rahman, A.; Delcea, M. Specific Domain V Reduction of Beta-2-Glycoprotein I Induces Protein Flexibility and Alters Pathogenic Antibody Binding Sci. Rep. 2021, 11 (1), 4542
2020	Kulke, M.; Langel, W. Molecular Dynamics Simulations to the Bidirectional Adhesion Signaling Pathway of Integrin ΑVβ3 Proteins Struct. Funct. Bioinforma. 2020, 88 (5), 679–688
2019	Kulke, M.; Uhrhan, M.; Geist, N.; Brüggemann, D.; Ohler, B.; Langel, W.; Köppen, S. Phosphorylation of Fibronectin Influences the Structural Stability of the Predicted Interchain Domain J. Chem. Inf. Model. 2019, 59 (10), 4383–4392
2019	Geist, N.; Kulke, M.; Schulig, L.; Link, A.; Langel, W. Replica-Based Protein Structure Sampling Methods II: Advanced Hybrid Solvent TIGER2hs J. Phys. Chem. B 2019, 123 (28), 5995–6006
2019	Janke, U.; Kulke, M.; Buchholz, I.; Geist, N.; Langel, W.; Delcea, M. Drug-Induced Activation of Integrin Alpha IIb Beta 3 Leads to Minor Localized Structural Changes PLoS One 2019, 14 (4), e0214969
2019	Kulke, M. A Molecular Model for an Adhesion Complex in the Extracellular Matrix of Bone Cells PhD Thesis, University of Greifswald, 2019
2018	Kulke, M.; Geist, N.; Möller, D.; Langel, W. Replica-Based Protein Structure Sampling Methods: Compromising between Explicit and Implicit Solvents J. Phys. Chem. B 2018, 122 (29), 7295–7307
2017	Kulke, M.; Geist, N.; Friedrichs, W.; Langel, W. Molecular Dynamics Simulations on Networks of Heparin and Collagen Proteins Struct. Funct. Bioinforma. 2017, 85 (6), 1119–1130
2014	Aliev, A. E.; Kulke, M.; Khaneja, H. S.; Chudasama, V.; Sheppard, T. D.; Lanigan, R. M. Motional Timescale Predictions by Molecular Dynamics Simulations: Case Study Using Proline and Hydroxyproline Sidechain Dynamics Proteins Struct. Funct. Bioinforma. 2014, 82 (2), 195–215