Picture of Madleen Busse

Dr. Ph.D. Madleen Busse

  • Targeted contrast agent design
  • Staining protocol development
  • Microscopic and nanoscopic X-ray CT

  • Contrast enhanced CT of soft tissue samples
  • 3D virtual histology
  • Specific targeting of sub-cellular structures

  • 1
    Scholz, Josef; Roiser, Nathalie; Braig, Eva-Maria; Petrich, Christian; Birnbacher, Lorenz; Andrejewski, Jana; Kimm, Melanie A.; Sauter, Andreas; Busse, Madleen; Korbel, Rüdiger; Herzen, Julia; Pfeiffer, Daniela: X-ray dark-field radiography for in situ gout diagnosis by means of an ex vivo animal study. Scientific Reports 11 (1), 2021 mehr… BibTeX Volltext ( DOI )
  • 2
    Gustschin, Alex; Riedel, Mirko; Taphorn, Kirsten; Petrich, Christian; Gottwald, Wolfgang; Noichl, Wolfgang; Busse, Madleen; Francis, Sheila E.; Beckmann, Felix; Hammel, Jörg U.; Moosmann, Julian; Thibault, Pierre; Herzen, Julia: High-resolution and sensitivity bi-directional x-ray phase contrast imaging using 2D Talbot array illuminators. Optica 8 (12), 2021, 1588 mehr… BibTeX Volltext ( DOI )
  • 3
    Braig, Eva-Maria; Roiser, Nathalie; Kimm, Melanie A.; Busse, Madleen; Andrejewski, Jana; Scholz, Josef; Petrich, Christian; Gustschin, Alex; Sauter, Andreas; Bodden, Jannis; Meurer, Felix; Korbel, Rüdiger; Pfeiffer, Franz; Herzen, Julia; Pfeiffer, Daniela: X-ray Dark-Field Radiography. Investigative Radiology, 2020, 1 mehr… BibTeX Volltext ( DOI )
  • 4
    Busse, Madleen; Marciniszyn, Jaroslaw P.; Ferstl, Simone; Kimm, Melanie A.; Pfeiffer, Franz; Gulder, Tanja: 3D‐Non‐Destructive Imaging through Heavy Metal‐Eosin Salt Contrast Agents. Chemistry – A European Journal, 2020 mehr… BibTeX Volltext ( DOI )
  • 5
    Kulpe, Stephanie; Dierolf, Martin; Günther, Benedikt; Brantl, Johannes; Busse, Madleen; Achterhold, Klaus; Gleich, Bernhard; Pfeiffer, Franz; Pfeiffer, Daniela: Dynamic K-edge Subtraction Fluoroscopy at a Compact Inverse-Compton Synchrotron X-ray Source. Scientific Reports 10 (1), 2020, 9612 mehr… BibTeX Volltext ( DOI )
  • 6
    Kulpe, Stephanie; Dierolf, Martin; Günther, Benedikt; Busse, Madleen; Achterhold, Klaus; Gleich, Bernhard; Herzen, Julia; Rummeny, Ernst; Pfeiffer, Franz; Pfeiffer, Daniela: K-edge Subtraction Computed Tomography with a Compact Synchrotron X-ray Source. Scientific Reports 9 (1), 2019, 13332 mehr… BibTeX Volltext ( DOI )
  • 7
    Ferstl, S; Busse, M.; Müller, M.; Kimm, M. A.; Drecoll, E.; Burkner, T.; Allner, S.; Dierolf, M.; Pfeiffer, D.; Rummeny, E. J.; Weichert, W.; Pfeiffer, F.: Revealing the Microscopic Structure of Human Renal Cell Carcinoma in Three Dimensions. IEEE Transactions on Medical Imaging, 2019, 1-1 mehr… BibTeX Volltext ( DOI )
  • 8
    Busse, Madleen; Müller, Mark; Kimm, Melanie A.; Ferstl, Simone; Allner, Sebastian; Achterhold, Klaus; Herzen, Julia; Pfeiffer, Franz: 3D Imaging of Soft-Tissue Samples using an X-ray Specific Staining Method and Nanoscopic Computed Tomography. Journal of Visualized Experiments (152), 2019 mehr… BibTeX Volltext ( DOI )
  • 9
    Busse, Madleen; Ferstl, Simone; Müller, Mark; Kimm, Melanie A.; Drecoll, Enken; Bürkner, Toni; Allner, Sebastian; Hehn, Lorenz; Dierolf, Martin; Achterhold, Klaus; Herzen, Julia; Pfeiffer, Daniela; Rummeny, Ernst J.; Weichert, Wilko; Pfeiffer, Franz: New staining tools and developments for 3D soft tissue CT imaging. Developments in X-Ray Tomography XII, SPIE, 2019 mehr… BibTeX Volltext ( DOI )
  • 10
    Müller, Mark; Kimm, Melanie A.; Ferstl, Simone; Allner, Sebastian; Achterhold, Klaus; Herzen, Julia; Pfeiffer, Franz; Busse, Madleen: Nucleus-specific X-ray stain for 3D virtual histology. Scientific Reports 8 (1), 2018, 17855 mehr… BibTeX Volltext ( DOI )
  • 11
    Busse, Madleen; Müller, Mark; Kimm, Melanie A.; Ferstl, Simone; Allner, Sebastian; Achterhold, Klaus; Herzen, Julia; Pfeiffer, Franz: Three-dimensional virtual histology enabled through cytoplasm-specific X-ray stain for microscopic and nanoscopic computed tomography. Proceedings of the National Academy of Sciences 115 (10), 2018, 2293-2298 mehr… BibTeX Volltext ( DOI )
  • 12
    Ferstl, Simone; Metscher, Brian; Müller, Mark; Allner, Sebastian; Dierolf, Martin; Busse, Madleen; Achterhold, Klaus; Gleich, Bernhard; Pfeiffer, Franz: Laboratory-based X-ray NanoCT Explores Morphology of a Zebrafish Embryo. Microscopy and Microanalysis 24 (S2), 2018, 184-185 mehr… BibTeX Volltext ( DOI )
  • 13
    Fenton, Jacob M.; Busse, Madleen; Rendina, Louis M.: Synthesis and DNA-Binding Studies of a Dinuclear Gadolinium(III)–Platinum(II) Complex. Aust. J. Chem. 68, 2015, 576 mehr… BibTeX Volltext ( DOI )
  • 14
    Busse, Madleen; Border, Emily; Junk, Peter C.; Ferrero, Richard L.; Andrews, Philip C.: Bismuth( iii ) complexes derived from α-amino acids: the impact of hydrolysis and oxido-cluster formation on their activity against Helicobacter pylori. Dalton Trans. 43 (48), 2014, 17980-17990 mehr… BibTeX Volltext ( DOI )
  • 15
    Busse, Madleen; Trinh, Iman; Junk, Peter C.; Ferrero, Richard L.; Andrews, Philip C.: Synthesis and Characterisation of Bismuth(III) Aminoarenesulfonate Complexes and Their Powerful Bactericidal Activity against Helicobacter pylori. Chemistry - A European Journal 19 (17), 2013, 5264-5275 mehr… BibTeX Volltext ( DOI )
  • 16
    Andrews, Philip C.; Busse, Madleen; Junk, Peter C.; Forsyth, Craig M.; Peiris, Roshani: Sulfonato-encapsulated bismuth(iii) oxido-clusters from Bi2O3 in water under mild conditions. Chemical Communications 48 (61), 2012, 7583 mehr… BibTeX Volltext ( DOI )
  • 17
    Andrews, Philip C.; Busse, Madleen; Junk, Peter C.; Forsyth, Craig M.; Peiris, Roshani: Sulfonato-encapsulated bismuth(iii) oxido-clusters from Bi2O3 in water under mild conditions. Chemical Communications 48 (61), 2012, 7583 mehr… BibTeX Volltext ( DOI )
  • 18
    Andrews, Philip C.; Busse, Madleen; Deacon, Glen B.; Ferrero, Richard L.; Junk, Peter C.; MacLellan, Jonathan G.; Vom, Amelia: Remarkable in vitro bactericidal activity of bismuth(iii) sulfonates against Helicobacter pylori. Dalton Transactions 41 (38), 2012, 11798 mehr… BibTeX Volltext ( DOI )
  • 19
    Andrews, Philip C.; Busse, Madleen; Deacon, Glen B.; Ferrero, Richard L.; Junk, Peter C.; Huynh, Katie K.; Kumar, Ish; MacLellan, Jonathan G.: Structural and solution studies of phenylbismuth(III) sulfonate complexes and their activity against Helicobacter pylori. Dalton Transactions 39 (40), 2010, 9633 mehr… BibTeX Volltext ( DOI )
  • 20
    Kulpe, Stephanie; Dierolf, Martin; Günther, Benedikt; Busse, Madleen; Achterhold, Klaus; Gleich, Bernhard; Herzen, Julia; Rummeny, Ernst; Pfeiffer, Franz; Pfeiffer, Daniela: K-edge Subtraction Computed Tomography with a Compact Synchrotron X-ray source. (anderer Eintrag) mehr… BibTeX Volltext ( DOI )
  • 21
    Kulpe, Stephanie; Dierolf, Martin; Günther, Benedikt; Brantl, Johannes; Busse, Madleen; Gleich, Bernhard; Pfeiffer, Franz; Pfeiffer, Daniela: Dynamic K-edge Subtraction Fluoroscopy at a Compact Inverse-Compton Synchrotron X-ray Source. (anderer Eintrag) mehr… BibTeX Volltext ( DOI )

  • SPIE Optical Engineering and Applications, Developments in X-ray Tomography XII, San Diego, USA, 11th – 15th August 2019; Oral Presentation: New Staining Tools and Developments for 3D Soft-Tissue CT Imaging
  • 7th EuCheMS Chemistry Congress, ACC Liverpool, UK, 26th – 30th August 2018; Oral Presentation: Tool development for 3D histology using microscopic and nanoscopic CT
  • International Conference X-ray Microscopy – XRM 2018, Saskatoon, Sasketchewan, Canada, 19th – 24th August 2018; Poster Presentation: Bismuth-Oxo-Cluster for Soft Tissue Staining
  • European Medical and Biological Engineering Conference (EMBEC’17) and Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC’17), Tampere, Finland, 11th June – 15th June 2017; Poster Presentation: Bismuth-Oxo-Cluster for Soft Tissue Staining.
  • SPIE - Medical Imaging Conference, Orlando, USA, 12th February – 17th February 2017; Oral Presentation: 3D histology of soft tissue samples using novel staining methods.
  • Wissenschaftsforum Chemie 2015, Dresden, Germany, 30th August – 3rd September 2015; Poster Presentation: Gadolinium Photon Activation Therapy for the Treatment of Brain Cancer.
  • Gordon Research Conference: Metals in Medicine; Andover, NH, USA, 22 – 27 June 2014; Poster presentation: Gadolinium Photon Activation Therapy for the Treatment of Brain Cancer.
  • 16th ICNCT - International Congress on Neutron Capture Therapy Conference, Helsinki, Finland, 14 – 20 June 2014; Oral Presentation and Key Note Lecture (Fairchild Award Winner 2014): Gadolinium Neutron Capture Therapy Agents Targeting Mitochondria; invited Chair of Chemistry Session.
  • 11th International Conference on Biology and Synchrotron Radiation (BSR), Hamburg, Germany, 8 -11 September 2013; Poster presentation: Feasibility of Gadolinium Photon Activation Therapy.
  • Wissenschaftsforum Chemie 2013, Darmstadt, Germany, 1 – 4 September 2013; Poster presentation I: Bismuth(III) sulfonates – Synthesis, Structure and Activity against H. pylori; Poster presentation II: Bismuth(III) amino arenesulfonates – Powerful Antibiotics against H. pylori
  • IUPAC – 44th World Chemistry Congress, Istanbul, Turkey, 11 – 16 August 2013; Oral presentation: Bismuth(III) amino arenesulfonates – Powerful Antibiotics against H. pylori; Poster presentation: Bismuth(III) Sulfonates – Synthesis, Structure and Activity against H. pylori.
  • IC11 – Inorganic Chemistry Conference, University of Western Australia, Perth, 4 – 8 December 2011; Oral presentation: Bismuth(III) Sulfonates – Synthesis, Structural Chemistry and Activity against H. pylori; Poster presentation: Bismuth(III) Sulfonate – Synthesis, Structural Chemistry and Activity against H. pylori.
  • Inorganic Chemistry Symposium, Monash University, Melbourne, 30th November 2011; Oral presentation: Bismuth(III) sulfonate clusters – Synthesis, Structural Insides and Activity against H. pylori; Poster presentation: Bismuth(III) sulfonate complexes – Synthesis, Structural Insights and Activity against H. pylori.
  • OZOM5 – 6th Australian Organometallic Meeting, University of Tasmania, Hobart,17 - 20 January 2011; Poster presentation: Structural and Solution Studies of Phenylbismuth(III) Sulfonate Complexes and their activity against Helicobacter pylori.
  • Wöhlertagung 2010, Universität Freiburg, Germany, 29 September – 1 October 2010; Poster presentation: Amino arylsulfonates and zwitterion formation – BiPh3 vs silver metathesis.
  • 3rd EuChemMS Chemistry Congress, Congress Centre Nürnberg, Germany, 29 August – 02 September 2010; Poster presentation: Structural and Solution Studies of Phenylbismuth(III) Sulfonate Complexes and their Activity against H. Pylori.
  • OZOM5 – 5th Australian Organometallic Meeting, University of New South Wales, Sydney,17 - 20 January 2010; Oral presentation: BiPh3 – Limitations in reactions involving zwitterion formation.

  • 04/2016-03/2018 Marie Skłodowska Curie Individual Fellowship
  • 04/2015-03/2016 Technical University of Munich Foundation Fellowship
  • 06/2014 Fairchild Award – 16th International Congress on Neutron Capture Therapy Conference, Helsinki, Finland.
  • 08/2013 Conference travel grant from Karl-Ziegler-Stiftung, August-Wilhelm-von-Hoffmann-Stiftung and Stiftungsfonds of GDCh
  • 05/2013 Fresh Science NSW state finalist 2013, Australia.
  • 03-06/2012 Postgraduate Publication Award from Monash University, Melbourne, Australia.
  • 12/2011 Don Stranks Award – Royal Australian Chemical Institute Inorganic Chemistry Division Conference, Perth, Australia
  • 11/2011 Poster Prize – Inorganic Chemistry Symposium, Melbourne, Australia.
  • 06/2008-07/2012 Faculty of Science International Tuition Fee Scholarship 2008, Monash University, Melbourne, Australia.
  • 02/2006-11/2006 DAAD scholarship (German Overseas Exchange Service) to undertake studies at Monash University, Melbourne, Australia.

  • 11/2016 Organization and Participation at “Herbstuniversität an der TUM”: One whole day workshop to explore MRT and CT with theoretical background and hands on experiments in the laboratories under the topic “Bringe Licht ins Dunkle - Medizinische Bildgebung”
  • 03/2016 Experimental Lecture with children aged 3-6 years with the theme ”What can swim? – How shape and weight can influence the properties of materials from our daily life.”
  • 10/2015 - present Design, Organization and Participation at “Tag der Offenen Tür” at TUM: Experimental lecture embedded in a theatre play designed for children: “Wer hat die Ü-Eier geklaut? Überführt mit Kommissar IME und Assistent TUM den Ü-Eier Dieb!“
  • 04/2015 - present Seminars for PhD students and Postdocs at the Technical University of Munich such as Networking Map, Mentoring, Coaching, etc.
  • 04/2015 Founder of the Lean In Circle “Lean In @ TUM” – a small group of ambitious, talented and passionate women that drive towards a leadership role – together we are stronger
  • 10/06/2014 Organisation and Moderation of a podiums discussion for higher degree research students and postdoctoral fellows “Insights into Academia and Beyond” (article published in The University of Sydney Chemistry Newsletter ChemNEWS, 2014, Issue 25, page 6)
  • 05/2014 Organisation of a lunch time session “Family and a Career in Science” – opportunity for young scientists to discuss challenges and share their experience regarding the topic provided
  • 03/2014- 12/2014 Organisation of an Early Career Researcher Network within The University of Sydney – Outcome: new seminar series for postdocs in 5 seminars
  • 03/2014 Organisation of a lunch time session “Resumé – Applying in Academia”
  • 02 and 04/2014 Seminars for PhD students at The University of Sydney and Monash University (Australia): “The 7 secrets of a highly successful PhD thesis”
  • 09/2013 Science Seminar (Research in Science) and Experimental Workshop (Chemistry of Life - covering topics of the teaching curriculum) for year 11 and 12 students at Werner-Heisenberg-Gymnasium, Riesa, Germany
  • 08/2013 Science Seminar (Research in Science) and Experimental Workshop (Chemistry of Life - covering topics of the teaching curriculum) for year 11 and 12 students at Thomas-Mann-Gymnasium, Oschatz, Germany (article published in local newspaper Oschatzer Allgemeine Zeitung (OAZ), 24 August 2013)
  • 08/2010 Science Seminar (What is it like to study chemistry) and Workshop (Who am I) for year 11 and 12 students at Glen Eira College, Melbourne, VIC

  • 2018 –Member of the American Chemical Society
  • 2009 –Member of the Royal Society of Chemistry
  • 2003 –Member, Gesellschaft Deutscher Chemiker

  • 04/2018-present Postdoctoral Researcher at Prof. Franz Pfeiffer’s Chair of Biomedical Physics, Physics Department, TUM Garching
  • 04/2016-03/2018 Marie Skłodowska Curie Individual Fellowship at the Chair of Biomeical Physics, Physics Department, TUM Garching
  • 04/2015-03/2016 Technical University of Munich Foundation Fellow hosted by Prof. Franz Pfeiffer, Chair of Biomedical Physics, Physics Department, TUM Garching
  • 10/2012-12/2014 Postdoctoral Research Fellow at The University of Sydney working with Assoc. Prof. Louis Rendina on synthesis and application of novel agents for 157-gadolinium photon activation therapy.
  • 06/2008-07/2012 PhD (chemistry) at Monash University under the supervision of Assoc. Prof. Philip Andrews and Prof. Peter Junk, Melbourne (Australia); Thesis title: Design and Development of Novel Bismuth Compounds as Potential Contrast Agents for Diagnostic Imaging and Antibiotics againstHelicobacter pylori (Grade: exceptional; language: English)
  • 09/2010-01/2011 Internship with Prof. Stefanie Dehnen at Philipps-University Marburg (Germany)
  • 10/2005-06/2008 M.Sc. (chemistry) at University of Leipzig (Germany) under the supervision of Prof. Christian Stark (Grade: exceptional, language: English)
  • 02/2006-11/2006 Student-Exchange–Honours-Program at Monash University, Melbourne (Australia); First-Class preliminary M.Sc. under the supervision of Assoc. Prof. Stuart Batten (Grade: first-class, language: English)
  • 10/2002-09/2005 B.Sc. (chemistry) at University of Leipzig (Germany) under the supervision of Prof. Norbert Sträter (Grade: exceptional, language: German)
  • 06/2002 Abitur (equivalent A-level) at Werner-Heisenberg-Gymnasium Riesa (Germany)
  • 1983 born in Eisenach (Germany)